Non-specific CD8+ T cells from NC revealed stronger cytotoxicity than from CHB patients and hepatitis B-related HCC patients, which presented as elevated induction of target HepG2.2.15 cell death (28.88 ± 1.80%; P<0.0001, SNK-q tests, Figure 5A). The gene discussed is CD8A; the disease is hepatocellular carcinoma.