In the tumor microenvironment CD49a-CD49b+Eomes+, NK cells can convert into CD49a+CD49b+Eomes+ and CD49a+CD49b-Eomesint NK cells (type 1 innate lymphoid cells) in response to cytokine-TGFβ signaling; however, intermediate group 1 innate lymphoid cells and group 1 innate lymphoid cells could not control local tumor growth and metastasis, and TGF-β signaling in NKp46+ cells suppress NK cell-mediated tumor immunosurveillance (57) (Figure 1). The gene discussed is TGFB1; the disease is neoplasm.