HAVCR2 and neoplasm: In addition, tumor-infiltrating NK cells in non-small-cell lung cancer and melanoma metastatic lymph nodes exhibit downregulation of the activation markers, CD69, NKp44, and HLA-DR (19, 56), while TIGIT, TIM-3, LAG-3, and PD-1 were upregulated in tumor-infiltrated NK cells, indicating that they tended toward exhaustion (57).