Further, they applied anti-NK1.1 monoclonal antibody, PK136to depletion of number of NK cells, or Kras mice with an Nfil3-/- mouse knockout model, and showed that depletion of NK cells significantly accelerated tumor development during tumor initiation, while depletion of NK cells during promotion and development had no effect on tumor development. The gene discussed is KRAS; the disease is neoplasm.