Sribava found that the ILC2 content in the small intestine was increased in mice with IgE-mediated food allergies (148), and the content of ILC2s was decreased in the small intestine after GATA-1 activity was reduced, indicating the roles of ILC2s and GATA-1 in IgE-mediated food allergies (146). This evidence concerns the gene IGHE and food allergy.