Considering the proteomic differences found in the two H. capsulatum morphologies, we can conclude that abundant proteins in the mycelial form without human homologs, such as saccharopine dehydrogenase (HCAG_01145) or the Y20 protein (HCAG_04745), may be future targets for the development of new prophylactic approaches to combat the development of histoplasmosis by inhibiting the dimorphic transition to the pathogenic yeast phase. Here, AASS is linked to histoplasmosis.