In pancreatic islet study by Hodson and his colleagues, ADCY5 silencing led to impaired glucose-induced cAMP increases and lower ATP concentrations at high glucose levels, in keeping with reduced mRNA expression of ADCY5 in patients with the ADCY5 SNP rs11708067, which increases the risk of type 2 diabetes (32). Here, ADCY5 is linked to type 2 diabetes mellitus.