HCRT and Obesity: In addition, animal studies have provided a possible link between obesity and migraine, since several vascular mediators (e.g., CGRP), pro-inflammatory biomarkers (e.g., interleukins, cytokines), or substances involved in the food intake and weight control (e.g., orexin) have an important role in both obesity and migraine (51–53) (see Figure 1).