In this study, insulin sensitivity (ISI-Stumwoll index) and oral glucose insulin sensitivity (OGIS-180 index) were significantly altered in migraine patients when compared with non-migraine patients (0.28 ± 0.12 vs. 0.18 ± 0.09; and 455.4 ± 59 vs. 515.7 ± 088.2, p < 0.01; respectively) (173). This evidence concerns the gene INS and migraine disorder.