In addition, animal studies have provided a possible link between obesity and migraine, since several vascular mediators (e.g., CGRP), pro-inflammatory biomarkers (e.g., interleukins, cytokines), or substances involved in the food intake and weight control (e.g., orexin) have an important role in both obesity and migraine (51–53) (see Figure 1). The gene discussed is HCRT; the disease is obesity due to melanocortin 4 receptor deficiency.