The most important factors for antiplatelet resistance in patients with AIS are due to poor adherence and concurrent use of other cyclooxygenase- 1 (COX- 1) inhibitors (56) and genetic factors like single nucleotide polymorphism (SNP) of the receptors (P2Y12, P2Y1, GPIIb−IIIa, collagen receptor, TXA2, etc.)and enzymes (COX-1&2). This evidence concerns the gene PTGS1 and androgen insensitivity syndrome.