BMAL1 and tuberous sclerosis: Moreover, the pathological activation of the mTOR pathway involved in LPS-induced increase in SWDs (265, 266) is responsible for the upregulation of the core clock gene product aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), also known as brain and muscle ARNT-Like 1 (BMAL1), as observed in a model of tuberous sclerosis complex, a neurological disorder displaying epileptic activity (333).