There is marked phenotypic-pleiotropy associated with variants in TBC1D24 including DEE, progressive myoclonic epilepsy, non-syndromic deafness, DOORS syndrome (deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures), an AHC-like phenotype, multifocal myoclonus, epilepsia partialis continua or ID (41, 105–109). This evidence concerns the gene TBC1D24 and deafness.