K-means cluster analysis shows that genes in cluster A, strongly enriched for myeloid activation, neutrophil activation and leukocyte degranulation are upregulated in DCS cases at T1, while genes in cluster B, enriched for immune system processes, cell surface receptor signaling and lymphocyte activation were upregulated at T2 in DCS cases. Here, CD177 is linked to Dorfman-Chanarin disease.