In mice with sepsis-associated organ damage, Ferlito et al. (2014) reported that CHOP expression was upregulated in the spleen, lungs, and liver, whereas exogenous H2S reduced the expression of CHOP in these organs, alleviated the inflammatory response, and improved the survival rate in septic mice, indicating that H2S had a protective role in sepsis by inhibiting ERS. Here, DDIT3 is linked to Sepsis.