MAPT and Alzheimer disease: Several groups have generated cortical organoids to model Alzheimer disease (AD) and recapitulated the molecular phenomena that are observed in AD, such as aggregation of β-amyloid, hyperphosphorylation of tau protein, and endosomal abnormalities (Lee et al., 2016; Raja et al., 2016; Lin et al., 2018; Gonzalez et al., 2018).