CRH and Anxiety: The function of sgPFC (subgenual PFC) – a term used interchangeably with subgenual anterior cingulate cortex (sgACC) (Drevets et al., 2008; Price and Drevets, 2012) – is moderately diminished during normal stress to disinhibit the CRH and the LC-NE systems and consequently to promote anxiety and arousal, while diminishing appetite and sleep.