Triptolide also mitigated pulmonary fibrosis partly by downregulating nicotinamide adenine dinucleotide phosphateoxidase 2 (NOX2) through the NF-κB pathway (Yuan et al., 2019) and increase the alveolar space (Hoyle et al., 2010). The gene discussed is NFKB1; the disease is pulmonary fibrosis.