VRK2 kinase-mediated phosphorylation of USP25 suppressed the deubiquitinating activity of USP25 and stabilized the molecular chaperone TRiC (Table 3), leading to the aggregation of misfolded proteins in neurodegenerative diseases (Kim et al., 2014; Kim et al., 2015). Here, MARVELD2 is linked to neurodegenerative disease.