Among these, six subfamilies include Ub-specific proteases (USPs), Ub C-terminal hydrolases (UCHs), ovarian tumour proteases (OTUs), Machado-Josephin domain-containing proteases (MJDs), MIU-containing novel DUB (MINDY), and zinc finger-containing ubiquitin peptidase 1 (ZUP1) (cysteine-dependent proteases). The gene discussed is ZUP1; the disease is ovarian neoplasm.