VRK2 kinase-mediated phosphorylation of USP25 suppressed the deubiquitinating activity of USP25 and stabilized the molecular chaperone TRiC (Table 3), leading to the aggregation of misfolded proteins in neurodegenerative diseases (Kim et al., 2014; Kim et al., 2015). The gene discussed is USP25; the disease is neurodegenerative disease.