ACE2 and Hypertension: Specific ACE-2 single nucleotide polymorphism (SNP) variants have been related to the risk of T2DM (Wu et al., 2017), susceptibility to T2DM in Asian population (Burrell et al., 2004), risk of T2DM with hypertension, and risk of T2DM related to left ventricular remodeling (Liu et al., 2018).