ACE2 and diabetes mellitus: On the other hand, others reported increased expression of ACE-2 levels in kidneys (Ye et al., 2004; Wysocki et al., 2006), serum, liver, and pancreas (Roca-Ho et al., 2017) in animal models of diabetes, and lung ACE-2 activity extrapolated from human data (Rao et al., 2020) supporting tissue-specific ACE-2 regulation (Riviere et al., 2005).