TNF and colorectal cancer: Additionally, formononetin (an isoflavone) was also recognized as one of potential ingredients in the treatment of UC, which might possess the prominent anti-inflammation and antiproliferative effect on human colorectal cancer by downregulating the expression of HIF-1α and inflammatory cytokines (Huang et al., 2015; Ong et al., 2019), such as TNF-α, NF-κB (Wang et al., 2012).