EGFR and inflammatory bowel disease: Especially, TNF signaling pathway exerts a broad spectrum of activities, including regulation of inflammation and the migration of intestinal epithelial cells (Armaka et al., 2008; Schliemann et al., 2011), and it has been confirmed that ErbB signaling can be activated by the phosphorylation of TNF-α-induced receptor, which modulates the intestinal wound healing of inflammatory bowel disease (Frey et al., 2009).