Chromene (benzopyran) and coumarin (chromen-2-one) moieties are present in a large number of biologically active compounds, and their derivatives are potent inhibitors of a variety of proteins, such as EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and telomerase associated with lung cancer (Manjinder et al., 2015; Manvendra et al., 2018; Al-Warhi et al., 2020; Oliveira-Pinto et al., 2020). This evidence concerns the gene EGFR and lung cancer.