Prior research from our group using a pre-clinical mouse model found that mice lacking negative regulators of noncanonical NF-κB signaling - such as the Nod-like receptor NLRP12-demonstrated increased noncanonical pathway activation and susceptibility to models of IBD and inflammation-driven colon tumorigenesis (Allen et al., 2012). Here, NFKB1 is linked to inflammatory bowel disease.