Compared with the analysis of SARS-CoV-2 affected lung tissue samples, we obtained 14 common targets of GA against COVID-19 (MMP13, SOD2, PPARGC1A, EPSTI1, SOCS3, PDK4, MAOB, SERPINB4, ICAM1, DNAH9, CFB, TLR2, TYMP, MMP9), those overlapping targets of GA-related targets and SARS-CoV-2 DEGs were considered as potential targets, the results of protein-protein interaction and network analysis showed that ICAM1, MMP9, TLR2, and SOCS3 had higher degree values, which may be core targets of GA for COVID-19 treatment. Here, EPSTI1 is linked to COVID-19.