SOCS3 and COVID-19: Our study suggests that ICAM1, MMP9, TLR2, and SOCS3 are a promising intervention target: SARS-CoV-2 infection aggravates the endothelin induction in multiple organs of COVID-19 patients via viral involvement in the host inflammatory and immune response, and the presence of elements within endothelial cells and the gathering of inflammatory cells (Varga et al., 2020).