In people with normal cognition with Aβ deposition, it can be observed that the content of cerebrospinal fluid Progranulin is related to the thickening of the occipital cortex and cognitive decline; this result reflects that the neuroinflammatory reaction in the preclinical stage of Alzheimer’s disease may cause the compensatory performance in the occipital lobe (Batzu et al., 2020). The gene discussed is GRN; the disease is early-onset autosomal dominant Alzheimer disease.