After adjustment for SCD, Aβ42, Aβ40, P-tau, and T-tau, multivariate logistic regression analysis showed that SCD and the increased CSF level of P-tau were still risk factors for POD; the increased CSF level of Aβ42 was still a protective factor for POD, as shown in Table 3. This evidence concerns the gene MAPT and Schnyder corneal dystrophy.