MAPT and Schnyder corneal dystrophy: There was an evidence that an increased tau protein in CSF deposition in SCD patients results in a decrease in glucose metabolism in the brain (Perrotin et al., 2012; Snitz et al., 2015; Buckley et al., 2017), a decrease in medial temporal lobe volume (Scheef et al., 2012), and a thinner cortex (Jessen et al., 2006; Saykin et al., 2006).