MAPT and Alzheimer disease: This APPPS1 mouse model (Radde et al., 2006) is particularly useful to study the progression of amyloidopathy as these mice exhibit alterations in Aβ CSF levels, Aβ brain load and Tau CSF levels in a temporal sequence and magnitude of Aβ and Tau changes observed in the CSF of patients with sporadic and dominantly inherited AD (Maia et al., 2013).