Neuropeptides, critical inducers of neurogenic inflammation, are primarily released from nociceptors following intense noxious stimulation and/or activation of different molecular sensors, such as TRP channels (e.g., TRPV1; Sousa-Valente and Brain, 2018; Yakubova and Davidyuk, 2021), G protein-coupled receptors [proteinase-activated receptor 2 (PAR2) and Mrgprb2] (Wei et al., 2016), sodium channels (Nav1.9; Bonnet et al., 2019), and mechanosensitive Piezo receptors (Mikhailov et al., 2019). Here, F2RL1 is linked to inflammation.