SHANK2 and epilepsy: One exception was the relatively strong enrichment of W3-HT, but not the other three transcripts, for genes related to epilepsy, in line with that (1) epilepsy is one of the comorbidities of ASD, (2) epilepsy symptoms were observed in individuals with SHANK2-related genetic variations (although rare) (Leblond et al., 2012), and (3) Shank2 expression is altered in epileptic humans and rat models (Fu et al., 2020).