SOD1 and amyotrophic lateral sclerosis: The misfolding and aggregation of amyloid-beta (Aβ) and tau in AD and superoxide dismutase type-1 (SOD1) in ALS results in a progressive loss of specific populations of neurons that is strongly associated with mitochondrial dysfunction, neuroinflammation and excitotoxicity (Andersen, 2004; Guo et al., 2013; Song et al., 2021).