In a later study, Poulsen et al. (2014) adopted this approach to characterize the oxidation isoforms of TTR in CSF from AD, MCI, and normal pressure hydrocephalus (NPH) patients and HCs, and an increased oxidation level of Cys10 in TTR isoforms was observed in AD and MCI compared to other groups. The gene discussed is TTR; the disease is Alzheimer disease.