Neurod1 has also been used to successfully reprogram reactive glial cells functional cortical neurons in stab-injured or Alzheimer’s disease mouse models and in adult non-human primates after ischemic stroke, which again offers the possibility to develop new therapeutical approaches for patients affected with Alzheimer’s disease (Guo et al., 2014; Ge et al., 2020). This evidence concerns the gene NEUROD1 and early-onset autosomal dominant Alzheimer disease.