Despite the fact that NEUROD1 expression levels have been reported not to be significantly changed in Alzheimer’s patients (Satoh et al., 2014), its overexpression into hippocampal progenitor cells increases dendritic spine density of hippocampal newborn neurons and results in a great improvement in spatial memory in the Alzheimer’s disease mouse model APPxPS1 (Richetin et al., 2015). Here, NEUROD1 is linked to early-onset autosomal dominant Alzheimer disease.