PLAT and stroke disorder: In the context of clinical studies, a small population study of 476 non-lacunar strokes treated with an IV infusion of tPA was interested in identifying possible circadian variation with thrombolytic intervention; patients who received IV thrombolysis at morning (0600–1200) and afternoon (1200–1800 h) time points exhibited less improvement on the NIH Stroke Scale compared to other time points.