In addition, disruptions to circadian rhythms and core clock gene function through exposure to light at night disrupts immune function and increases neuroinflammation (Walker et al., 2020), that has been corroborated in an ischemic murine model in which 24 h of exposure to dLAN post stroke increased pro-inflammatory response (TNF-α, IL-6, and IL-1) in the ipsilateral cortex that can further amplify secondary damage of the infarct (Weil et al., 2020). Here, CLOCK is linked to Stroke.