In the context of clinical studies, a small population study of 476 non-lacunar strokes treated with an IV infusion of tPA was interested in identifying possible circadian variation with thrombolytic intervention; patients who received IV thrombolysis at morning (0600–1200) and afternoon (1200–1800 h) time points exhibited less improvement on the NIH Stroke Scale compared to other time points. Here, PLAT is linked to Stroke.