CRYAB and neoplasm: Since the data suggest the transport of large subunits of HSP through the exosomal pathway and their significant role in tumor biology, we analyzed the expression profile of HSPB5, HSPB6, and HSPB8 in the cargo of exosomes derived from wild-type and cisplatin-resistant variants from both A2780 and SKOV3 cell lines (Figure 2b and 2c(Fig. 2)).