Given the lack of data about the role of small HSPs (Hsp20, Hsp22, and alpha-B Crystallin) in chemoresistance in ovarian cancer, we aimed to identify and compare the expression of Hsp20 (HSPB6), Hsp22 (HSPB8), and alpha-B Crystallin (HSPB5) in two cell lines: A2780 and SKOV3, both in two variants: wild type and cisplatin-resistant. This evidence concerns the gene HSPB6 and ovarian cancer.