In several studies, it has been reported that the cells secrete high levels of proinflammatory cytokines (IL-1β, IL-6, and tumor necrosis factor [TNF]) in patients with COVID-19.2,3 Unfortunately, there is no proven effective therapy to decrease the cytokine levels, and the clinical trials to find one have been going on.1–3 As reported in septic shock-associated acute renal failure, CRRT with sepsis membrane effectively removes TNF-α, IL-6, IL-8, and IFN γ.4 Therefore, the following question arises: would CRRT decrease cytokine levels in patients with COVID-19? The gene discussed is TNF; the disease is COVID-19.