In the KEGG pathway analysis, 35 pathways related to Influenza A, Kaposi sarcoma-associated herpesvirus infection, human T-cell leukemia virus 1 infection, toxoplasmosis, hepatitis C, Epstein-Barr virus infection, viral carcinogenesis, peroxisome, T cell receptor signaling pathway, natural killer cell-mediated cytotoxicity, hypoxia-inducible factor-1 signaling pathway, tumor necrosis factor (TNF) signaling pathway, relaxin signaling pathway, FOXO signaling pathway, apelin signaling pathway, and chemokine signaling pathway were identified (Figure 3D, 3E and Supplementary Table 3). Here, APLN is linked to hepatitis C virus infection.