The results of GO and KEGG enrichment analysis showed that the effects of VA on anti-CHOL and anti-COVID-19 were mainly through the regulation of immune responses such as anti-viral and anti-inflammatory actions, immunoregulation, influenza A, human T-cell leukemia virus 1 infection, viral carcinogenesis, T cell receptor signaling, natural killer cell-mediated cytotoxicity, TNF signaling, and chemokine signaling. This evidence concerns the gene TNF and COVID-19.