Regarding the correlations between NVC alterations and specific aPL positivity, Bongard et al. have described more capillary abnormalities in ACL-positive than aCL-negative SLE patients, while Bernardino et al. have reported a significant association between ACL and the absence of hemorrhage in APS patients [26, 31]. This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.