The AE-QoL was developed with input from patients with various types of angioedema including both bradykinin-mediated (e.g., HAE-C1INH) and histamine-mediated angioedema [4]; thus, it is more disease-specific than generic HRQoL instruments but may not address all aspects of HAE-related HRQoL. Here, SERPING1 is linked to angioedema.