Our results showed: among the population ≤ 60 years old, rs3821236, rs11893432 and rs11889341 of STAT4 were significantly associated with increased T2D risk; among the population with BMI < 24, rs11889341 and rs7574865were significantly associated with increased risk of T2D; among the non-drinking population, rs3821236, rs11893432, rs11889341 and rs7574865 had a certain association with the increased risk ofT2D; in the analysis of whether the participants smoked, there was no significant association between STAT4 gene polymorphism and T2D risk. The gene discussed is STAT4; the disease is type 2 diabetes mellitus.