This agrees with the view of Lecarpentier et al12 that decreased free PlGF levels in preeclampsia / HELLP are a consequence of higher sFlt-1 rather than decreased PlGF production of the placenta.12 With this perspective in mind, our previous observation that despite greater sFlt-1 elevation, free PlGF levels were not reduced in women with AFLP in comparison to women with preeclampsia, was quite surprising.11 Our present finding that total PlGF levels are significantly raised in women with AFLP now explains this observation. This evidence concerns the gene PGF and preeclampsia.