According to the adenosine hypothesis of schizophrenia, reduced adenosinergic activity would trigger a compensatory upregulation of striatal A2AR, which in turn would suppress the activation of the indirect pathway inducing a hyperdopaminergic state (Lara and Souza 2000; Lara et al. 2006; Boison et al. 2012). This evidence concerns the gene ADORA2A and schizophrenia.