HLA-B and toxic epidermal necrolysis: Moreover, HLA-B*15:21 allele showed significant association between AEDs-induced SJS/TEN and general Thai population (2/46 (4.3%) vs 2/470 (0.42%), OR 10.636, 95%CI: 1.462–77.359; p < 0.042), while the association between HLA-B*15:21 allele and AEDs-tolerant controls did not reach statistical significance (p = 0.214).