In addition, acacetin provides strong protection against myocardial ischemia/reperfusion (or hypoxia/reoxygenation) injury by inhibiting inflammation, oxidation, and apoptosis via activating AMPK/Nrf2 signaling [17, 18], and reducing cardiotoxicity induced by the chemical therapy drug doxorubicin via activating Sirt1/AMPK signal molecules [19]. This evidence concerns the gene SIRT1 and myocardial ischemia.