For example, circSDHC contributed to cell invasion and proliferation in renal cell carcinoma [21]; circ-Ttc3 promoted the inflammatory response and oxidative stress in sepsis-induced acute kidney injury [22]; hsa_circ_0123190 was significantly downregulated in lupus nephritis and it might impede the progression of lupus nephritis [23]. This evidence concerns the gene TTC3 and hereditary clear cell renal cell carcinoma.