INS and Insulin resistance: The possible mechanisms for increased serum FABP4 linking to blunted insulin sensitivity may be as follows: first, overexpression of FABP4 contributes to endoplasmic reticulum stress, inflammatory response and oxidative stress [34], which in turn may lead to insulin resistance; second, elevated serum FABP4 levels are accompanied visceral adiposity, including ectopic fat deposition in islets of the pancreas, which may induce glucose intolerance, insulin resistance and β-cell dysfunction [35, 36].