Here, we found that multiple lipid receptor-related pathways associated with lipid transportation and signaling might be influenced in a B-cell-specific manner, involving LDLR (cg16647139), SORL1 (cg26556630), SCARF1 (cg17028259), etc. In B-cells, these gene body CpG loci were estimated to be completely methylated among individuals exposed to GDM but were completely unmethylated among those not exposed to GDM. This evidence concerns the gene SORL1 and gestational diabetes.