TGFB1 and acute myeloid leukemia: In details, Geyh et al. addressed the contribution of AML-MSCs to hematopoietic failure in patients and verified the significant growth deficiency and osteogenic differentiation capacity together with specific methylation signatures affecting skeletal development and stromal support for long-term HSC maintenance, which was subsequently confirmed by TGF-β1-mediated functional inhibition of osteogenic differentiation and hematopoietic support capacity [1, 32].