Furthermore, distinguished from the aforementioned gene expression profiling and epigenetic modification pattern, AML-MSC-derived exosome revealed an abnormal spectrum of miRNA profiling (e.g., upregulated miR-26a-5p and miR-101-3p, downregulated miR-23b-5p, and miR-339-3p) and predicted leukemogenesis-associated gene expression (e.g., upregulated KRBA2 and RRBP1, downregulated EZH2 and GSK3β) [33]. This evidence concerns the gene EZH2 and acute myeloid leukemia.