CASP8 and cancer: While analyzing multiple cancer disorders (Fig. 4I), we found highly variable expression among genes implicated in cancer: EEF1A1, GNAS, NPM1, PIM1, and RHOA are known oncogenes; H3F3A, PTPRC, SMARCB1, and B2M are possible oncogenes; and CASP8, JAK1, and PRKAR1A are known tumor suppressor genes [31].