Arthritis genes included ANXA1, LTB, B2M, TNFRSF1B, HLA-DRA, SLC11A1, S100A12, ITGB2, HLA-DRB1, TNFRSF1A, HLA-C, SERPINA1, HLA-DB1, FCGR3A, CXCR2, HLA-B, TMSB4X, and S100A9 (Fig. 4B) and with significant expression. Here, B2M is linked to arthritic joint disease.