In our study, we used three in vivo murine tumor models to show that tumor-infiltrating PVRIG+ NK cells are more exhausted (higher CD96, TIGIT, Tim-3, PD-1 and NKG2A expression) compared with PVRIG− tumor-infiltrating NK cells (with the exception of NKG2A on MCA205 tumor model-derived PVRIG+ NK cells). This evidence concerns the gene CD96 and neoplasm.