TNF and neoplasm: Anti-hPVRIG mAb significantly enhanced the cytokine secretion (IFN-γ and TNF-α) and degranulation (CD107a) of NK cells from PBMCs in co-culture with SW620 cells (Fig. 7e) and significantly improved the cytotoxicity of purified NK cells against SW620 tumor cells at indicated effector/target ratios in vitro (Fig. 7f).