PVRIG and neoplasm: However, along with anti-PVRIG mAb treatment, depletion of NK cells significantly accelerated tumor growth and shortened the overall survival of tumor-bearing mice (Fig. 6d, e), meanwhile, depletion of CD8+ T cells resulted in a very similar fashion (Fig. 6f, g), suggesting that the presence of NK cells and CTLs both contributes to the therapeutic efficacy of anti-PVRIG mAb.