Furthermore, COAD patients were divided into two groups (PVRIG high and PVRIG low) based on their intratumoral PVRIG gene expression as reported by the TCGA database, not surprisingly, patients with high PVRIG expression exhibited shorter overall survival compared to those with low PVRIG expression across multiple cutoff values (Fig. 1d, Additional file 1: Fig. S1), suggesting the potential of PVRIG as a prognostic marker in predicting the outcomes of COAD patients. The gene discussed is PVRIG; the disease is colon adenocarcinoma.