To answer the question of whether ITGAV on the tumor cells alone or in combination with E- and P-selectins in the tumor environment has a functional effect on intraperitoneal carcinomatosis formation, PaCa 5061 ITGAV KD and PaCa 5061 control cells were intraperitoneally injected into selectin-deficient and wild-type Pfp−/−/Rag2−/− mice (12 animals each group for the selectin-deficient mice, 14 and 15 selectin-competent animals for the control PaCa 5061 and the ITGAV KD group, respectively). This evidence concerns the gene PRF1 and neoplasm.