PTF1A and neoplasm: After subcutaneous tumor cell injection (10 pfp−−/rag2−− mice each s.c. injected with control and ITGAV KD PaCa 5061, respectively), 9 of 10 animals (90%) injected with control cells and 7 of 10 (70%) mice injected with ITGAV KD cells developed s.c. tumors until the experiment was terminated after 199 days.