As mentioned above, PaCa 5061 cells formed subcutaneous primary tumors in and around the injection channel after intraperitoneal injection: tumor weight in the group of wild-type mice with ITGAV KD cells was significantly reduced (mean of 116 mg, P = 0.003) and a synergistic effect could be observed for the selectin-deficient animals with ITGAV KD cells. The gene discussed is ITGAV; the disease is neoplasm.