Following the genomic region of MAPK11, we found 10 locations on 2 islands with the first island having 4 methylation targets (CpG1: cg23755154, cg15036874, cg16054907, cg13577505) to present a strong positive correlation of expression-methylation for all 4 cancers (exception is probe cg15036874 in BRCA with an R = -0.095). Here, MAPK11 is linked to cancer.