PTK2 and ovarian carcinoma: For instance, Snail serves as a positive regulator of EMT and glucose metabolism in gastric cancer [9], and HK2 was reported to increase glycolytic activity and ovarian cancer cell invasiveness through upregulation of the EMT activator, focal adhesion kinase (FAK) [10, 11], indicating that the overlapping mechanisms exist to affect both EMT and aerobic glycolysis.