Since previous reports indicated that HK2-mediated ovarian cancer cell invasion is mediated through the FAK/ERK1/2 pathway [10], and FAK promotes EMT in cancer cells by upregulating Twist1 and Snail expression [21, 22], we examined whether HK2 regulates EMT in EC cells in a FAK-dependent manner. Here, SNAI1 is linked to ovarian carcinoma.