CDH2 and hepatocellular carcinoma: In addition, Dai B et al. reported that the protein expression of epithelial biomarker E-cadherin was increased, while expression of the mesenchymal markers N-cadherin and snail were decreased after ARHGAP11A knock-down in hepatocellular carcinoma cells, indicating the role of RhoGAP in regulation of cell conjunction and metastatic process [26].