To investigate the effect of ARHGAP10 on NSCLC progression, we detected the ARHGAP10 expression in multiple NSCLC cell lines and lung epithelial cell line BEAS-2B by RT-qPCR and Western blot (Fig. 2a, b), the expression of ARHGAP10 was significantly down-regulated in lung cancer cell lines, especially in the A549 and NCI-H1299 cell lines. The gene discussed is ARHGAP10; the disease is non-small cell lung carcinoma.