Four months ago, she presented to the pediatric ward for edema and foam urine, and further examination demonstrated that antinuclear antibodies (ANA) 181.65 U/ml (normal range, 0–12 U/ml), anti-double-stranded DNA antibody (dsDNA) 643.19 IU/ml (normal range, 0–30 IU/ml), Complement 3 0.12 g/L (normal range, 0.79–1.17 g/L), Complement 4 0.03 g/L (normal range, 0.17–0.31 g/L), skin rash, urine sugar and protein positive, which made the diagnosed of systemic lupus erythematosus (SLE) established according to American College of Rheumatology (ACR) criteria. Here, BTG3 is linked to systemic lupus erythematosus.