Xu et al. pointed out that SASH1 regulates the expression of Mitf in the nucleus by acting as a scaffold molecule that participates in the assembly of the SASH1-MITF molecular complex and promotes the hyperpigmentation phenotype in the pathogenesis of DUH and other dermatoses related to abnormal pigmentation [10]. This evidence concerns the gene SASH1 and dyschromatosis universalis hereditaria.