TRIM28 (KAP1), a transcriptional co-repressor that is recruited to ERV repeat elements through KRAB-Zinc finger transcription factors [48, 59], is also expressed at higher levels in AML patient samples with low R/G ratios, as is the histone H3.3 chaperone DAXX (death domain associated protein). Here, DAXX is linked to acute myeloid leukemia.