BAZ2B and alpha thalassemia spectrum: BAZ2B (Bromo-domain Adjacent to Zinc finger domain 2B), which binds to acetylated histone H3 lysine 14 (H3K14Ac) [21] and the chromatin remodeler ATRX (Alpha Thalassemia/mental Retardation syndrome X) [38] also correlate with elevated R/G ratios.